Endocrinology

Diabetes

Blood pressure conflict

Diabetes Canada still prints blood pressure <130/80. In Québec use systolic <130, no diastolic target.

Screening

Who to test
  • INESSS Institut national d'excellence en santé et services sociaux
  • DC Diabetes Canada
DecisionGuideline
Roster screening
≥40 every 3 years Fasting plasma glucose and/or HbA1c.
  • Do not replace this with INESSS PMN 888046. Québec has no guideline.

Diabetes Canada chapter 4 opens in a new tabQuébec · no guideline

Unattached adults
≥15 and at least 2 risk factors Unattached adults 18–75 only. Not roster screening.
  • HbA1c

How often

  • Score 15–20 every 5 years;
  • above 20 yearly
  • CANRISK ≥33 if used instead

FINDRISC opens in a new tabCANRISK opens in a new tabINESSS

Diagnose

  • DC Diabetes Canada
DecisionGuideline
Diagnose
Any of these tests
  • HbA1c
  • Fasting plasma glucose
  • Glucose tolerance test
  • Random plasma glucose

Confirm

  • Symptoms: one result is enough.
  • No symptoms: repeat on another day.
  • Two different tests both above threshold: diagnosed.

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Diagnostic thresholds
≥6.5%
HbA1c
Prediabetes 6.0–6.4%

Diabetes Canada

≥7.0
Fasting plasma glucose
Impaired fasting glucose 6.1–6.9

Diabetes Canada

≥11.1
75 g OGTT, 2 h
Impaired glucose tolerance 7.8–11.0

Diabetes Canada

≥11.1
Random plasma glucose
With classic symptoms

Diabetes Canada

Treatment target
≤7.0%
HbA1c most
Most adults
  • ≤6.5% if low hypoglycemia risk
  • 7.1–8.5% if frail
  • 7.1–8.0% if functionally dependent

Adjust

  • Tighter or looser by hypoglycemia risk and frailty.

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Investigate

After the diagnosis is confirmed

Baseline tests for complications and cardiovascular risk. Repeat kidney and lipids on the yearly interval, not at every titration visit.

  • DC Diabetes Canada
DecisionGuideline
Lipids
At diagnosis
  • Every 1–3 years if untreated
  • 3–6 months after starting therapy
  • Fasting if triglycerides >4.5
  • INESSS PMN 628004 checks a lipid profile before adjusting drugs.
  • Last 3 months OK.
  • Do not replace this with the unattached-adult 5-year screen.

Diabetes Canada chapter 25 opens in a new tabINESSS opens in a new tabQuébec · no lipid CPG

Electrocardiogram
Resting electrocardiogram every 3–5 years If age >40, duration >15 years and age >30, end-organ damage, or at least one cardiovascular risk factor.

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Eyes
Type 2 at diagnosis
  • Optometrist or ophthalmologist.

Repeat

  • Every 1–2 years if none or minimal.
  • Type 1: 5 years after diagnosis once age ≥15.

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Treat

  • RAMQ Régie de l'assurance maladie du Québec
  • DC Diabetes Canada
DecisionGuideline
First-line type 2
Metformin Start 250–500 mg PO BID with meals. Titrate slowly.
  • Insulin now if metabolic decompensation.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

Insulin now
Do not wait on HbA1c Metabolic decompensation or severe symptomatic hyperglycemia.

Diabetes Canada 2024 chapter 13

After Metformin
ASCVD
High CV risk
GLP-1 RA or SGLT2 inhibitor even if HbA1c is at target.
  • Prefer with Metformin.
  • GLP-1 RA with MACE evidence: Dulaglutide, Liraglutide, subcutaneous Semaglutide.
  • SGLT2 inhibitor with MACE evidence: Canagliflozin, Empagliflozin.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

Heart failure
SGLT2 inhibitor even if HbA1c is at target.
  • Dapagliflozin or Empagliflozin.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

CKD
SGLT2 inhibitor even if HbA1c is at target.
  • Canagliflozin, Dapagliflozin, or Empagliflozin.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

>1.5%
Above HbA1c target
Metformin plus a second class at the start
  • Do not wait on Metformin monotherapy if asymptomatic and that far above target.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

No cardiorenal priority
Individualize the second class
  • Weight: GLP-1 RA, GIP/GLP-1 RA, or SGLT2 inhibitor.
  • Cost: sulfonylurea.
  • Weight-neutral: DPP-4 inhibitor.

Do not

  • Two incretins together.
  • Sulfonylurea plus meglitinide.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

Still above target
Basal insulin Keep Metformin, incretins, and SGLT2 inhibitors.
  • Stop sulfonylureas and meglitinides if two or more prandial insulin injections a day.
  • Check RAMQ before claims.

Diabetes Canada 2024 chapter 13 opens in a new tabRAMQ drug list opens in a new tab

Metformin start
DrugDoseDuration
Metformin250–500 mg PO BID with mealsOngoing
Metformin XR500–1000 mg PO DIE at supperOngoing

Usual add-on starts are INESSS PMN 628004 examples for older or frail adults. Titration and eGFR live in that protocol. Check RAMQ.

Adults adding a second antihyperglycemic to Metformin
DrugDoseHow often
SGLT2 inhibitors
Empagliflozin10 mg PODIE, morning
Dapagliflozin5–10 mg PODIE, morning
Canagliflozin100 mg PODIE, morning
GLP-1 receptor agonists
Dulaglutide0.75 mg SC1×/sem
Liraglutide0.6 mg SCDIE
Semaglutide0.25 mg SC1×/sem
Sulfonylurea
Gliclazide40–80 mg PO with mealsBID
Basal insulin
Insulin NPH or Glargine4–10 unitsDIE

Follow-up

  • INESSS Institut national d'excellence en santé et services sociaux
  • DC Diabetes Canada
DecisionGuideline
HbA1c
Every 3 months until at target then every 6 months
  • Last 3 months OK before starting drugs.
  • Type 2 on an antidiabetic.

INESSS opens in a new tabChapter 9 opens in a new tab

Kidney
Creatinine, eGFR, and uACR at least yearly
  • Last 3 months OK before starting drugs.
  • Check more often if heavy proteinuria, known chronic kidney disease, or acute kidney injury risk.

INESSS opens in a new tabChapter 29 opens in a new tab

Blood pressure

Québec, not Diabetes Canada
  • INESSS Institut national d'excellence en santé et services sociaux
  • DC Diabetes Canada
DecisionGuideline
<130
DiffersSystolic
Systolic <130, no diastolic Diabetes is high cardiovascular risk, so drugs from systolic 130–139.

INESSS 2026 opens in a new tab

<130/80
  • Still posted.
  • Do not prefer this in Québec.
  • Hypertension Canada 2025 matches INESSS.

Chapter 26 opens in a new tabDiabetes Canada 2018

Reviewed 24 August 2026 against the official sources below.

Sources